Chartreusin

Chartreusin

$230.00 - 5 mg

$805.00 - 25 mg

All prices in Australian dollars

Code
BIA-C1124
Synonyms
Lambdamycin, NSC 5159, 747, 1293, X465A, G 261A
CAS #
6377-18-0
Molecular Formula
C32H32O14
Molecular Weight
640.6
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

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Product Data Sheet

Application Notes

Chartreusin is an antitumor antibiotic that binds to GC-rich tracts in DNA, with a clear preference for B-DNA over Z-DNA. It inhibits RNA synthesis and causes single-strand scission of DNA via the formation of free radicals. Chartreusin is also a potent inhibitor of topoisomerase II.

References

  • Chartreusin, a new antibiotic produced by Streptomyces chartreusis, a new species. Leach, B.E. et al., J.Am.Chem.Soc. 1953, 75, 4011.
  • Biochemical characterisation of elsamicin and other coumarin-related antitumor agents as potent inhibitors of topoisomerase II. Lorico A. and Long B.H. Eur. J. Cancer 1993, 14, 1985.
  • Chartreusin, elsamicin A and related anti-cancer antibiotics. Portugal J. Curr. Med. Chem. Anticancer Agents. 2003, 3, 411.

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