Chaetoviridin A

Chaetoviridin A

$180.00 - 0.50 mg

$630.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-C1907
Synonyms
5'-Hydroxychaetoviridine F
CAS #
128252-98-2
Molecular Formula
C23H25ClO6
Molecular Weight
432.9
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in DMSO, methanol, chloroform or acetone

Download Data Sheets

Product Data Sheet

Application Notes

Chaetoviridin A, an azaphilone isolated from Chaetomium sp., is a potent antifungal against plant pathogenic fungi in vitro and in vivo, suppressing the development of rice blast and wheat leaf rust by over 80​% at a concentration of 62.5 mcg/mL. Chaetoviridin A has antitumor properties and inhibits tumor promotion induced by 12-​O-​tetradecanoylphorbol-​13-​acetate via an anti-inflammatory effect. Chaetoviridin A has moderate inhibitory activity against cholesteryl ester transfer protein (CETP).

References

  • Antifungal activity against plant pathogenic fungi of chaetoviridins isolated from Chaetomium globosum. Park J-H. et al. J Antibiot. 1999, 52, 160.
  • Cytotoxic nitrogenated azaphilones from the deep-​sea-​derived fungus Chaetomium globosum MP4-​S01-​7. Wang W. et al. J Nat Prod. 2020, 83, 1157.
  • Azaphilones inhibit tumor promotion by 12-​O-​tetradecanoylphorbol-​13-​acetate in two-​stage carcinogenesis in mice. Yasukawa K. et al. Oncology 1994, 51, 108.

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