Chaetomin is an epidithiodioxopiperazine metabolite first isolated from Chaetomium cochliodes by Waksman and Bugie in 1944 as an antibiotic. Its structure was resolved in the 1970s comprising a non-symmetric bis-epidithiodioxopiperazine with both hemispheres having a core N,N’-dimethyldiketopiperazine linked by a bisulfide bridge. Chaetomin is an important chemo-taxonomic standard for characterising the genus Chaetomium. Chaetomin is a potent antitumor agent, inhibiting hypoxia-inducible transcription. Chaetomin is used extensively as a molecular reagent and is the subject of over 150 citations in Scifinder.
- Chetomin, a new antibiotic substance produced by Chaetomium cochliodes. I. Formation and properties. Waksman S.A. and Bugie E., J. Bact. 1944, 48, 527.
- Sporidesmins. XIII. Ovine ill-thrift in Nova Scotia. III. Characterization of chetomin, a toxic metabolite of Chaetomium cochliodes and Chaetomium globosum. Safe S. and Taylor A., Perkin Trans. 1: Org. Bioorg. Chem. 1972, 4, 472.
- Mycotoxin production by Chaetomium spp. and related fungi. Sekita S. et al., Can. J. Microbiol. 1981, 27, 766.