Chaetoglobosin A is a mycotoxin of the cytochalasin class produced by Chaetonium globosum. Like other cytochalasins, chaetoglobosin A has a broad biological profile with antitumor, nematocidal, antifungal, antibiotic and antiamebic activity. Chaetoglobosin A targets the cytoskeleton of chronic lymphocytic leukemia cells, inducing apoptosis.
- Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton. Knudsen P.B. et al. Leukemia 2014, 28, 1289.
- Nematicidal activity of chaetoglobosin A poduced by Chaetomium globosum NK102 against Meloidogyne incognita. Yang et al. J Ag Food Chem. 2013, 61, 41.
- Antifungal metabolites produced by Chaetomium globosum No.04, an endophytic fungus isolated from Ginkgo biloba. Zhang G. et al. Indian J Microbiol. 2013, 53, 175.