Chaetoglobosin A

Chaetoglobosin A

$180.00 - 0.10 mg

$630.00 - 0.50 mg

All prices in Australian dollars

Code
BIA-C1927
CAS #
50335-03-0
Molecular Formula
C32H36N2O5
Molecular Weight
528.64
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

Download Data Sheets

Product Data Sheet

Application Notes

Chaetoglobosin A is a mycotoxin of the cytochalasin class produced by Chaetonium globosum. Like other cytochalasins, chaetoglobosin A has a broad biological profile with antitumor, nematocidal, antifungal, antibiotic and antiamebic activity. Chaetoglobosin A targets the cytoskeleton of chronic lymphocytic leukemia cells, inducing apoptosis.

References

  • Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton. Knudsen P.B. et al. Leukemia 2014, 28, 1289.
  • Nematicidal activity of chaetoglobosin A poduced by Chaetomium globosum NK102 against Meloidogyne incognita. Yang et al. J Ag Food Chem. 2013, 61, 41.
  • Antifungal metabolites produced by Chaetomium globosum No.04, an endophytic fungus isolated from Ginkgo biloba. Zhang G. et al. Indian J Microbiol. 2013, 53, 175.

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