$126.00 - 1 mg
$441.00 - 5 mg
All prices in Australian dollars
- CGP049090, NSC 153111
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
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Cercosporin (CGP049090) is a perylenequinone reported in 1957 as the causative agent of soy bean purple speck disease due to the fungal pathogen, Cercsopsorium kikuchii, which is widely found in species of Cercosporium. Cercosporin phytotoxicity is light-activated and this process contributes to a wider biological profile as a photodynamic antiviral and antitumor active. Cercosporin is an antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumor cell lines.
- Cercosporin. A pigment of Cercosporina kikuchii Matsumoto et Tomoyasu. I. Cultivation of fungus, isolation and purification of pigment. Kuyama S. & Tamura T. J. Am. Chem. Soc. 1957, 79, 5725.
- Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. Lepourcelet M. et al., Cancer Cell. 2004, 5, 91.