Cercosporamide

Cercosporamide

$310.00 - 0.50 mg

$1,085.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-C1015
CAS #
131436-22-1
Molecular Formula
C16H13NO7
Molecular Weight
331.3
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

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Product Data Sheet

Application Notes

Cercosporamide was originally identified as a host-selective phytotoxin and broad spectrum antifungal agent isolated from Cercosporidium henningsii. More recently, cercosporamide was shown to inhibit a cell wall integrity pathway mediated through a serine/threonine protein kinase, Pkc1, that is central to cell wall biosynthesis. It is both a potent (IC50<50nM) and selective inhibitor of Pkc1 kinase.

References

  • Discovery of cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high-throughput screening. Sussman A. et al., Eukaryot Cell. 2004, 3, 932.
  • Cloning and characterization of KNR4, a yeast gene involved in (1,3)-beta-glucan synthesis. Hong Z. et al., Mol. Cell Biol. 1994, 14, 1017.
  • The structure and biological activity of cercosporamide from Cercosporidium henningsii. Sugawara F. et al., J. Org. Chem. 1991, 56, 909.

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