Cercosporamide was originally identified as a host-selective phytotoxin and broad spectrum antifungal agent isolated from Cercosporidium henningsii. More recently, cercosporamide was shown to inhibit a cell wall integrity pathway mediated through a serine/threonine protein kinase, Pkc1, that is central to cell wall biosynthesis. It is both a potent (IC50<50nM) and selective inhibitor of Pkc1 kinase.
- Discovery of cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high-throughput screening. Sussman A. et al., Eukaryot Cell. 2004, 3, 932.
- Cloning and characterization of KNR4, a yeast gene involved in (1,3)-beta-glucan synthesis. Hong Z. et al., Mol. Cell Biol. 1994, 14, 1017.
- The structure and biological activity of cercosporamide from Cercosporidium henningsii. Sugawara F. et al., J. Org. Chem. 1991, 56, 909.