Cellocidin

Cellocidin

$140.00 - 5 mg

$490.00 - 25 mg

All prices in Australian dollars

Code
BIA-C1449
Synonyms
Aquamycin, Butynesiamide, Lenamycin,
CAS #
543-21-5
Molecular Formula
C4H4N2O2
Molecular Weight
112.1
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

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Application Notes

Cellocidin is a small neutral alkyne produced by a number of Streptomyces species, first discovered by Suzuki and colleagues in 1958. Cellocidin has a broad antibacterial, antifungal and antitumor profile due to its ability to react with endogenous thiols like cysteine and glutathione. Cellocidin occurs as a weak active in many bioassays using actinomycete crude extracts and is thus a useful standard for chemical and bioassay dereplication.

References

  • Cellocidin, a new antibiotic. Suzuki S. et al., J. Antibiot. 1958, 11, 81.
  • The structure of cellocidin. Suzuki S. & Okuma K. J. Antibiot. 1958, 11, 84.
  • Antagonistic mechanism of sulfhydryl compounds on cellocidin activity. Yoneyama K. et al., J. Antibiot. 1978, 31, 065.

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