Calphostin C

Calphostin C

$225.00 - 0.10 mg

$790.00 - 0.50 mg

All prices in Australian dollars

Code
BIA-C1014
Synonyms
UCN 1028 C, PKF 115-384
CAS #
121263-19-2
Molecular Formula
C44H38O14
Molecular Weight
790.8
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Calphostin C (PKF115-584) is a perylenequinione isolated from the fungus, Cladosporium cladosporioides. Calphostin C is a potent and specific inhibitor of protein kinase C (PKC), with inhibition being light dependent. Calphostin C inhibits cell proliferation and induces apoptosis in vitro. Calphostin C is an antagonist of Tcf4/b-catenin signalling, inhibiting the expression of survivin and inducing apoptosis in several tumor cell lines.

References

  • Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities. Kobayashi E. et al., J. Antibiotics, 1989, 42, 1470.
  • Calphostins, novel and specific inhibitors of protein kinase C. II. Chemical structures. Kobayashi E. et al., J. Antibiotics, 1989, 42, 1475.
  • Inhibition of protein kinase C by calphostin C is light-dependent. Bruns R.F. et al., Biochem. Biophys. Res. Commun., 1991, 176, 288.
  • Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. Lepourcelet M. et al., Cancer Cell. 2004, 5, 91.

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