Bleomycin complex

Bleomycin complex

$225.00 - 10 mg

$790.00 - 50 mg

All prices in Australian dollars

Code
BIA-B1203
Synonyms
Blenoxane, Bleo
CAS #
9041-93-4
Molecular Formula
C55H84N17O21S3 (for A2)
Molecular Weight
1415.6 (for A2)
Purity
>98% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in water and methanol, with moderate ethanol solubility.

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Product Data Sheet

Application Notes

Bleomycin is a complex of 11 glycopeptide antitumor antibiotics originally isolated from Streptomyces verticillus in 1972. The dominant components of the complex are bleomycin A2 and B2, which typically represent >90% of the total weight. Bleomycins have found clinical application in the treatment of a range of tumors. Bleomycins act by intercalation of DNA and RNA. In the presence of oxygen and metal ions, notably copper and iron, bleomycins form a pseudo-enzyme that induces DNA cleavage.

References

  • Chemistry of bleomycin. IX. The structures of belomycin and phleomycin. Takita T. et al., J. Antibiot. 1972, 25, 755.
  • Structural basis for the deoxyribonucleic acid affinity of bleomycins. Kross J. et al., Biochemistry 1982, 21, 3711.
  • Specificity of deoxyribonucleic acid cleavage by bleomycin, phleomycin and tallysomycin. Kross et al., Biochemistry 1982, 21, 4310.

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