Bleomycin complex
Bleomycin complex
$225.00 - 10 mg
$790.00 - 50 mg
All prices in Australian dollars
- Code
- BIA-B1203
- Synonyms
- Blenoxane, Bleo
- CAS #
- 9041-93-4
- Molecular Formula
- C55H84N17O21S3 (for A2)
- Molecular Weight
- 1415.6 (for A2)
- Purity
- >98% by HPLC
- Long Term Storage
- -20°C
- Solubility
- Soluble in water and methanol, with moderate ethanol solubility.
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Application Notes
Bleomycin is a complex of 11 glycopeptide antitumor antibiotics originally isolated from Streptomyces verticillus in 1972. The dominant components of the complex are bleomycin A2 and B2, which typically represent >90% of the total weight. Bleomycins have found clinical application in the treatment of a range of tumors. Bleomycins act by intercalation of DNA and RNA. In the presence of oxygen and metal ions, notably copper and iron, bleomycins form a pseudo-enzyme that induces DNA cleavage.
References
- Chemistry of bleomycin. IX. The structures of belomycin and phleomycin. Takita T. et al., J. Antibiot. 1972, 25, 755.
- Structural basis for the deoxyribonucleic acid affinity of bleomycins. Kross J. et al., Biochemistry 1982, 21, 3711.
- Specificity of deoxyribonucleic acid cleavage by bleomycin, phleomycin and tallysomycin. Kross et al., Biochemistry 1982, 21, 4310.
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