Bischloroanthrabenzoxocinone

Bischloroanthrabenzoxocinone

$287.00 - 0.50 mg

$1,005.00 - 2.50 mg

All prices in Australian dollars

Synonyms
BABX
CAS #
866022-28-8
Molecular Formula
C28H24O7Cl2
Molecular Weight
543.4
Purity
>99% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Clear

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Application Notes

Bischloroanthrabenzoxocinone ((-)BABX) is a selective inhibitor of Type II fatty acid synthesis (FASII). BABX showed IC50 values of 11.4 and 35.3 μg/ml in the S. aureus and E. coli FASII assays, respectively, with comparable antibacterial activities. FASII is essential to bacterial cell viability and is a promising target for the development of novel antibiotics. More recently, BABX has been shown to inhibit agonist binding to Liver X receptors (LXR). These receptors regulate the expression of the ABCA1 gene, which mediates the efflux of cholesterol from cells.

References

  • Determination of selectivity and efficacy of fatty acid synthesis inhibitors. Kodali S. et al., J. Biol. Chem. 2005, 280, 1669.
  • Anthrabenzoxocinones from Streptomyces sp. as Liver X receptor ligands and antibacterial agents. Herath K. B. et al., J. Nat. Prod. 2005, 68, 1437.

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