Bilaid A1 (FvVf-NH2) is the semi-synthetic analogue of Bilaid A, an unusual tetrapeptide isolated from an Australian estuarine isolate of Penicillium sp. MST-MF667. Conversion of the terminal carboxylate to its corresponding amide enhanced the μ-opioid agonist potency leading to the design of more potent analogues, bilorphin and bilactorphin.
- A tetrapeptide class of biased analgesics from an Australian fungus targets the μ-opioid receptor. Dekan Z. et al. Proc Nat Acad Sci. 2019, 116, 22535.