$302.00 - 1 mg
$1,057.00 - 5 mg
All prices in Australian dollars
- Berninamycin, U27810
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.
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Berninamycin A is an antibiotic discovered in 1976 from a strain of Streptomyces. Berninamycin A is a macrocyclic "peptide" comprising atypical amino acids linked to thiazole and oxazoles. Chemically very complex, berninamycin A is an inducer oftipA, a gene that controls the bacterial transcription regulators,tipAL andtipAS, that are central to multidrug resistance. Berninamycin A is closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1.
- Berninamycin. I. The structure of berninamycinic acid. Liesch, J.M. et al., J.Am.Chem.Soc. 1976, 98, 299.
- Mode of action of berninamycin. An inhibitor of protein biosynthesis. Reusser F. Biochem. 1969, 8, 3303.
- Identification of a chemical inhibitor of the oncogenic transcription factor Forkhead Box M1. Radhakrishnan et al., Cancer Res. 2006, 19, 9731.