Berninamycin A

Berninamycin A

$302.00 - 1 mg

$1,057.00 - 5 mg

All prices in Australian dollars

Code
BIA-B1121
Synonyms
Berninamycin, U27810
CAS #
58798-97-3
Molecular Formula
C51H51N15O15S
Molecular Weight
1146.1
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Berninamycin A is an antibiotic discovered in 1976 from a strain of Streptomyces. Berninamycin A is a macrocyclic "peptide" comprising atypical amino acids linked to thiazole and oxazoles. Chemically very complex, berninamycin A is an inducer oftipA, a gene that controls the bacterial transcription regulators,tipAL andtipAS, that are central to multidrug resistance. Berninamycin A is closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1.

References

  • Berninamycin. I. The structure of berninamycinic acid. Liesch, J.M. et al., J.Am.Chem.Soc. 1976, 98, 299.
  • Mode of action of berninamycin. An inhibitor of protein biosynthesis. Reusser F. Biochem. 1969, 8, 3303.
  • Identification of a chemical inhibitor of the oncogenic transcription factor Forkhead Box M1. Radhakrishnan et al., Cancer Res. 2006, 19, 9731.

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