Barbatic acid

Barbatic acid

Barbatic acid

$245.00 - 1 mg

$860.00 - 5 mg

All prices in Australian dollars

Code
BIA-B2989
Synonyms
Barbatinic acid, Rhizoic acid, Coccellic acid
CAS #
17636-16-7
Molecular Formula
C19H20O7
Molecular Weight
360.4
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol and DMSO.

Download Data Sheets

Product Data Sheet

Application Notes

Barbatic acid is a didepside first isolated by Stenhouse and Groves in 1880 from the lichen Usnea barbata. Barbatic acid is widely distributed across Usnea species, as well as other lichens including Cladonia and Cladia. Barbatic acid is potently active against the A549 human lung cancer cell line with IC50 of 1.8 ± 0.7 µM and is moderately active against HeLa, MCF and DU cancer cell lines. Barbatic acid demonstrates potent activity against the trematode Schistosoma mansoni after 60 minutes’ exposure.

References

  • Stenhouse J. & Groves C.E. (1880). Beiträge zur geschichte der orcine: Betorcinol und einige seiner derivate. Justus Liebig's Annalen der Chemie, 203, 285.
  • Martins M. et al. (2017). Barbatic acid offers a new possibility for control of Biomphalaria glabrata and schistosomiasis. Molecules 22, 568.
  • Reddy S.D. et al. (2019). Comprehensive analysis of secondary metabolites in Usnea longissima (lichenized ascomycetes, Parmeliaceae) using UPLC-ESI-QTOF-MS/MS and pro-apoptotic activity of barbatic acid. Molecules 24, e2270.

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