$368.00 - 5 mg
$105.00 - 1 mg
All prices in Australian dollars
- Bacitracin A1, Bacitracin A2a, NSC 4573, Baciliquin
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in ethanol, methanol, DMF or DMSO.
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Bacitracin A is the major analogue of the bacitracin complex of cyclic peptides, active against Gram-positive bacteria. Although first reported in 1945, the structure of the bacitracins was not fully elucidated until 1995. Bacitracins form a complex with C55-isoprenyl pyrophosphate and a metal ion to inhibit dephosphorylation and the transport of polysaccharides, peptidoglycans and lipopolysaccharides to the growing cell wall. Bacitracin is used clinically as a topical treatment for skin infections.
- Bacitracin: A new antibiotic produced by a member of the B. subtilis group. Johnson B.A. et al., Science 1945, 102, 376.
- Mechanism of action of bacitracin: Complexation with metal ion and C55-isoprenyl pyrophosphate (molecular model/chelating agents/ternary complex/cell wall synthesis/peptidoglycan). Stone K.J. & Strominger J.L., Proc. Nat. Acad. Sci. 1971, 68, 3223.
- Total structures and antimicrobial activity of bacitracin minor components. Ikai Y. et al., J. Antibiot. 1995, 48, 233.