Bacitracin A

Bacitracin A

$368.00 - 5 mg

$105.00 - 1 mg

All prices in Australian dollars

Code
BIA-B1784
Synonyms
Bacitracin A1, Bacitracin A2a, NSC 4573, Baciliquin
CAS #
22601-59-8
Molecular Formula
C66H103N17O16S
Molecular Weight
1422.69
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.
Clear

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Application Notes

Bacitracin A is the major analogue of the bacitracin complex of cyclic peptides, active against Gram-positive bacteria. Although first reported in 1945, the structure of the bacitracins was not fully elucidated until 1995. Bacitracins form a complex with C55-isoprenyl pyrophosphate and a metal ion to inhibit dephosphorylation and the transport of polysaccharides, peptidoglycans and lipopolysaccharides to the growing cell wall. Bacitracin is used clinically as a topical treatment for skin infections.

References

  • Bacitracin: A new antibiotic produced by a member of the B. subtilis group. Johnson B.A. et al., Science 1945, 102, 376.
  • Mechanism of action of bacitracin: Complexation with metal ion and C55-isoprenyl pyrophosphate (molecular model/chelating agents/ternary complex/cell wall synthesis/peptidoglycan). Stone K.J. & Strominger J.L., Proc. Nat. Acad. Sci. 1971, 68, 3223.
  • Total structures and antimicrobial activity of bacitracin minor components. Ikai Y. et al., J. Antibiot. 1995, 48, 233.

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