Azidamfenicol

Azidamfenicol

$194.00 - 1 mg

$679.00 - 5 mg

All prices in Australian dollars

Code
BIA-A1485
Synonyms
Azidoamphenicol, Leukomycin N
CAS #
13838-08-9
Molecular Formula
C11H13N5O5
Molecular Weight
295.3
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Clear

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Application Notes

Azidamfenicol is a semi-synthetic chloramphenicol in which the nitro moiety is replaced with a methylsulphone and the dichloroacetamide is replaced with azidoacetamide, first synthesised at Bayer in 1959. Azidamfenicol is a broad spectrum antibiotic with good activity against Gram negative and anaerobic bacteria. Azidamfenicol acts by binding to the 23S sub-unit of the 50S ribosome, inhibiting protein synthesis. Azidamfenicol has received little research attention with only a few literature citations.

References

  • 1-p-Nitrophenyl-2-azidoacetylaminopropane derivatives. Meiser W. & Domagk G. 1959 US Patent 2,882,275.

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