Avermectin B1a

Avermectin B1a

$177.00 - 5 mg

$620.00 - 25 mg

All prices in Australian dollars

Synonyms
5-O-Demethylavermectin A1a, C 076B1a
CAS #
65195-55-3
Molecular Formula
C48H72O14
Molecular Weight
873.1
Purity
>99% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Clear

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Application Notes

Avermectin B1a is the major component (>80%) of a commercially available anthelmintic used to control parasitic nematodes in livestock. Avermectin B1a contains a sec-butyl residue in the 25-position. In vitro and in vivo studies have shown that this analogue is the more potent analogue in the commercial product.

References

  • Avermectin B1a irreversibly blocks postsynaptic potentials at the lobster neuromuscular junction by reducing muscle membrane resistance. Fritz L.C. et al., Proc Natl Acad Sci USA 1979, 76, 2062.
  • Solubilization and characterization of a high affinity ivermectin binding site from Caenorhabditis elegans. Cully D.F. et al., Mol Pharmacol. 1991, 40, 326.
  • Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics. Wolstenholme A.J. and Rogers A.T. Parasitology 2005, 131, S85-95.

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