Avermectin B1a, delta2-
Δ2-Avermectin B1a is an irreversible base degradation product of avermectin found in animals treated with avermectin and in the environment. Δ2-Avermectin B1a is formed by rearrangement of the naturally-occurring Δ3-group to the 2-position. Although less active than the parent, Δ2-avermectin B1a is nonetheless active at 1 ppm.
- Base-catalyzed isomerization of avermectins. Pivnichny J.V. et al., J. Agric. Food Chem. 1988, 36, 826.
- Direct determination of avermectins in plasma at nanogram levels by High-Performance Liquid Chromatography. Pivnichny J.V. et al., J. Pharm. Sci. 1980, 72, 1447.