Avenanthramide E
Application Notes
Avenanthramide E is a member of complex of phenolics produced by oats (Avena sativa) isolated and synthesised by Collins, Food Research Centre, Agriculture Canada in 1989. Structurally avenanthramides are a fusion of cinnamic and anthranilic acids. Specifically, avenanthramide E is a conjugate of ferulic acid and anthranilic acid. Avenanthramide E acts as a plant phytoalexin and antioxidant to protect oats in response to pathogen attack. Avenathramide E has been patented as a lipoxygenase inhibitor and is the demethyl analogue of the antiallergic drug, tranilast.
References
- Oat phenolics: Avenanthramides, novel substituted N-cinnamoylanthranilate alkaloids from oat groats and hulls. Collins F.W. J. Agric. Food Chem. 1989, 37, 60.
- Avenanthramides – A group of phenolic antioxidants in oats. Dimberg L.H. et al. Cereal Chem. 1993, 70, 637.
- Avenanthramides, distinctive hydroxycinnamoyl conjugates of oat, Avena sativa L.: An update on the biosynthesis, chemistry, and bioactivities. Pretorius C.J. & Dubery I.A. Plants 2023, 12, 1388.



