Avenaciolide
Application Notes
Avenaciolide, a bicyclic bis-butyrolactone, was isolated from Aspergillus avenaceus in 1963 as an antifungal agent. Avenaciolide inhibits glutamate transport and is also thought to act as an atypical ionophore.
References
- Avenaciolide, an antifungal lactone from Aspergillus avenaceus. Brookes D. et al., J. Chem. Soc. 1963, 5385.
- Avenaciolide: a specific inhibitor of glutamate transport in rat liver mitochondria. McGivan J.D. & Chappell J.B. Biochem. J. 1970, 116, 37P.
- Ionophoric actions of avenaciolide on mitochondrial cations. Harris E.J. & Wimhurst J.M. Arch. Biochem. Biophys. 1974, 162, 426.