Aureusimine B

Aureusimine B

$256.00 - 1 mg

$896.00 - 5 mg

All prices in Australian dollars

Code
BIA-A1309
Synonyms
Phevalin
CAS #
170713-71-0
Molecular Formula
C14H16N2O
Molecular Weight
228.3
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Clear

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Application Notes

Aureusimine B (phevalin) is a small molecular weight monoketopiperazine formed non-ribosomally by the fusion of phenylalanine and valine. Aureusimine B was isolated from S. aureus in 2010 as one of a pair of related metabolites, controversially identified as virulence factors in the pathology of Golden Staph. Aureusimine B is also an inhibitor of the protease, calpain.

References

  • Staphylococcus aureus nonribosomal peptide secondary metabolites regulate virulence. Wyatt M.A. et al., Science 2010, 329, 294.
  • Aureusimines in Staphylococcus aureus are not involved in virulence. Sun F. et al., PLoS 2010, 5, e15103.
  • Phevalin, a new calpain inhibitor, from a Streptomyces sp. Alvarez M.E. et al., J. Antibiot. 1995, 48, 1165.

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