$205.00 - 0.50 mg
$718.00 - 2.50 mg
All prices in Australian dollars
- Propionylpyrrothione, Farcinin
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.
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Aureothricin is an antibiotic first described by Umezawa and co-workers in Japan in 1949. Resurgent interest in this class of microbial metabolites was stimulated by the discovery of their selective antitumor activity. Aureothricin is a more hydrophobic analogue of thiolutin, but has received only limited attention. Members of this class, notably thiolutin, are potent inhibitors of bacterial and yeast RNA polymerases, inhibitors of mannan and glucan formation in fungi, and inhibitors of tumor-cell induced angiogenesis in vivo.
- Studies on a common hydrolysis product of thiolutin and aureothricin. Celmer W. D. and Solomons I.A. Antibiotics Annual 1953, 622.
- Anticancer property of dithiolopyrrolones. Webster J.M. et al., 2000, US Patent 6,020,360.
- Thiolutin inhibits yeast ribonucleic acid polymerases. Tipper D.J. J. Bacteriol. 1973, 116, 245.
- Thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiae. Mode of action. L133 Antimicrob Agents Chemother. 1973, 3, 729.