Asukamycin

Asukamycin

$283.00 - 0.50 mg

$991.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-A1600
Synonyms
Asukamycin A, AM 1024
CAS #
61116-33-4
Molecular Formula
C31H34N2O7
Molecular Weight
546.6
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.
Clear

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Application Notes

Asukamycin is an unusual trienoic acid amide metabolite produced by Streptomyces nodosus, reported by Omura and colleagues at the Kitasato Institute, Japan, in 1976. Asukamycin belongs to the manumycin class that comprises two trienoic acid amides pivoted on a central cyclohexenone ring to give the molecule an unprecedented angular geometry. Asukamycin is active against Gram positive bacteria, tumor cell lines and protozoans, notably coccidia. Asukamycin’s cell toxicity is accompanied by activation of Caspases 3 and 8.

References

  • A new antibiotic, asukamycin, produced by Streptomyces. Omura S. et al., J. Antibiot. 1976, 29, 876.
  • The manumycin-group metabolites. Sattler I. et al., J. Antibiot. 2000, 53, 221.
  • Antitumor activity of asukamycin, a secondary metabolite from the actinomycete bacterium Streptomyces nodosus subspecies asukaensis. Shipley P.R. et al., Int. J. Mol. Med. 2009, 24, 711.

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