Aspochalasin M is a minor analogue of the aspochalasin class of anti-tumor actives discovered by researchers at the Institute of Marine Drugs and Food, China in 2009. Aspochalasin M was isolated from Spicaria elegans using an OSMAC (one species many compounds) fermentation strategy to explore the biosynthetic potential of the fungus. Interestingly, aspochalasin M itself was inactive against several tumor cell lines.
- Spicochalasin A and new aspochalasins from the marine-derived fungus Spicaria elegans. Lin Z. et al., Eur. J. Org. Chem. 2009, 3045.