Asperphenamate

Asperphenamate

$174.00 - 1 mg

$610.00 - 5 mg

All prices in Australian dollars

Code
BIA-A1643
CAS #
63631-36-7
Molecular Formula
C32H30N2O4
Molecular Weight
506.6
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.
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Application Notes

Asperphenamate is an unusual ester of N-benzoylphenylalanine and N-benzoylphenylalaninol isolated from Aspergillus flavipes and first reported by Clark and co-workers in 1977. Since then, asperphenamate has been found in a broad range of Pencillium and Aspergillus species and even in plants, as a product of endophytic fungi. Asperphenamate has weak antitumor activity. Recently, a more soluble analogue, BBP, was found to induce autophagic cell death in tumor cells, a process modulated by a JNK-dependent Atg4 upregulation involving ROS production.

References

  • Two metabolites from Aspergillus flavipes. Clark A.M. et al., J. Nat. Prod. (Lloydia) 1977, 40, 146.
  • Synthesis of asperphenamate, a novel fungal metabolite. Clark A.M. and Hufford C.D., Phytochem. 1978, 17, 552.
  • Two new Penicillium species Penicillium buchwaldii and Penicillium spathulatum, producing the anticancer compound asperphenamate. Frisvad J.C., FEMS Microbiol. Lett. 2013, 339, 77.

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