Aspergillusidone D
Application Notes
Aspergillusidone D is a dibrominated depsidone of the nidulin family of fungal metabolites. Aspergillusidone D was first isolated from a marine-derived sponge, Aspergillus unguis, only when cultured on PDB media containing KBr. Aspergillusidone D demonstrates a range of bioactivities, including weak cytotoxicity against several human cell lines, aromatase inhibition and antimicrobial activity against B. subtilis, S. aureus and S. cerevisiae.
References
- Sureram S. et al. (2013). Directed biosynthesis through biohalogenation of secondary metabolites of the marine-derived fungus Aspergillus unguis. RSC Adv., 3, 1781.
- Morshed M. et al. (2018). Expanding antibiotic chemical space around the nidulin pharmacophore. Org. Biomol. Chem., 16, 3038.