Aspergillusidone D is a dibrominated depsidone of the nidulin family of fungal metabolites. Aspergillusidone D was first isolated from a marine-derived sponge, Aspergillus unguis, only when cultured on PDB media containing KBr. Aspergillusidone D demonstrates a range of bioactivities, including weak cytotoxicity against several human cell lines, aromatase inhibition and antimicrobial activity against B. subtilis, S. aureus and S. cerevisiae.