Ascochlorin

Ascochlorin

$301.00 - 0.50 mg

$1,055.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-A1115
Synonyms
LL-Z 1272 gamma, Ilicicolin D
CAS #
26166-39-2
Molecular Formula
C23H29ClO4
Molecular Weight
404.9
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
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Application Notes

Ascochlorin is an antitumor fungal metabolite which specifically inhibits matrix metalloproteinase-9 (MMP-9) activity through suppression of activator protein-1 (AP-1)-dependent induction of MMP-9 gene expression. Via AP-1 suppression, ascochlorin selectively kills MX-1 cells, a human breast cancer cell line lacking estrogen receptors. Ascochlorin also shows activity against Newcastle disease and herpes simplex viruses.

References

  • Ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1-mediated gene expression through the ERK1/2 signaling pathway: inhibitory effects of ascochlorin on the invasion of renal carcinoma cells. Hong S. et al., J. Biol. Chem. 2005, 280, 25202.
  • Selective cytotoxicity of ascochlorin in ER-negative human breast cancer cell lines. Sakaguchi K. et al., Biochem. Biophys. Res. Commun. 2005, 329, 46.
  • Ascochlorin derivatives as ligands for nuclear hormone receptors. Togashi M. et al., J. Med. Chem. 2003, 46, 4113.

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