Arjunolic acid

Arjunolic acid

$232.00 - 1 mg

$813.00 - 5 mg

All prices in Australian dollars

Code
BIA-A1754
Synonyms
Urjinolic acid
CAS #
465-00-9
Molecular Formula
C30H48O5
Molecular Weight
460.66
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.
Clear

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Application Notes

Arjunolic acid is a pentacyclic triterpenoid first isolated from the tropical hardwood, Terminalia arjuna, and its structure resolved by researchers at University of Nottingham, UK. Subsequently, arjunolic acid was found in a diverse range of hardwood species. Arjunolic acid has antifungal, antibacterial, antioxidant, cardioprotectant and antitumor activity. Arjunolic acid stabilizes the ligand-binding domain of peroxisome proliferator-activated receptor-α (PPARα) and increases its expression during cardiac hypertrophy. Arjunolic acid is potentially useful in the treatment of type 1 diabetes by preventing hyperglycemia-induced activation of MAPKs, PKC, NF-kB signaling cascades.

References

  • The chemistry of extractives from hardwoods. XVIII. The constitution of arjunolic acid, a triterpene from Terminalia arjuna. King F.E. et al., J. Chem. Soc. 1954, 3995.
  • Extractives from the New Zealand Myrtaceae. VI. Arjunolic acid from the heartwood of Metrosideros umbellate. Corbett R.E & Bailey C.R., Aust. J. Chem. 1963, 16, 191.
  • Extractives of Australian timbers. XVI. The constituents of the wood of Eugenia crebrinervis (syn. Syzigium crebrinerve) and Eugenia gustavioides (syn. Cleistocalyx gustavioides). Bannon C.D. et al., Aust. J. Chem. 1979, 29, 1135.
  • Arjunolic acid, a peroxisome proliferator-activated receptor α agonist, regresses cardiac fibrosis by inhibiting non-canonical TGF-β signaling. Bansal T. et al., J. Biol. Chem. 2017, 292, 16440.

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