Aranciamycin A
Application Notes
Aranciamycin A is an anthracycline bearing a methyl-L-rhamnose sugar in the 2-O position. Aranciamycin A has antitumor and Gram positive antibiotic activity and is a potent inhibitor of Clostridium histolyticum collagenase, with an IC50 = 3.7 x 10-7M.
References
- Metabolites of microorganisms. Aranciamycin. Keller-Schierlein W. et al. Helv Chim Acta 1970, 53, 779.
- The sugar component of aranciamycin: 2-0-methyl-L-rhamnose. Keller-Schierlein W. and Muller A. Experientia 1970, 26, 929.
- Aranciamycin analogs generated by combinatorial biosynthesis show improved antitumor activity. Luzhetskyy A. et al. Appl Microbiol Biotech 2008, 80, 15.