Apoptolidin

Apoptolidin

$290.00 - 0.10 mg

$1,014.00 - 0.50 mg

All prices in Australian dollars

Code
BIA-A1007
CAS #
194874-06-1
Molecular Formula
C58H96O21
Molecular Weight
1129.4
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Clear

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Application Notes

Apoptolidin, originally isolated from a Nocardiopsis sp., induces apoptotic cell death in rat glial cells transformed with the adenovirus E1A oncogene (IC50 = 11 ng/ml). Apoptolidin is among the most selective cytotoxic agents tested by the NCI in human cancer cell lines. Although the apoptotic activity of apoptolidin correlates with F0F1-ATPase inhibition, recent evidence suggests the existence of a secondary biological target or more complex mode of action.

References

  • Correlation of F0F1-ATPase inhibition and antiproliferative activity of apoptolidin analogues. Wender P.A. et al., Org. Lett. 2006, 8, 589.
  • Apoptolidin: induction of apoptosis by a natural product. Daniel P.T. et al., Angew. Chem. Int. Ed. Engl. 2006, 45, 872.
  • Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase. Salomon A.R. et al., Proc. Natl Acad. Sci. USA 2000, 97, 14766.

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