Apicidin C

Apicidin C

$215.00 - 0.50 mg

$755.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-A2982
CAS #
366448-28-4
Molecular Formula
C33H47N5O6
Molecular Weight
609.76
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

Download Data Sheets

Product Data Sheet

Application Notes

Apicidin C is the valine analogue of the rare cyclic tetrapeptide, apicidin, produced by Fusarium sp.. The apicidins are histone deacetylase inhibitors and have potent and broad spectrum antitumor, antiparasitic and antiprotozoan activity. The apicidins inhibit quorum sensing in bacterial infections.

References

  • Structure, histone deacetylase, and antiprotozoal activities of apicidins B and C, congeners of apicidin with proline and valine substitutions. Singh S. et al. Organic Letters 2001, 3, 2815.
  • Structure and chemistry of apicidins, a class of novel cyclic tetrapeptides without a terminal α-Keto epoxide as inhibitors of histone deacetylase with potent antiprotozoal activities. Singh S. et al. J Org Chem. 2002, 67, 815.
  • Methods and compositions for the inhibition of quorum sensing in bacterial infections. Pearce C. et al. WO2017197303 A1 2017-11-16.

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