$146.00 - 1 mg
$511.00 - 5 mg
All prices in Australian dollars
- ICI 69653
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
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Aphidicolin is a tetracyclic diterpene antibiotic isolated from fungi, notably Cephalosporium, Nigrospora, Harziella and Phoma. Aphidicolin has antibiotic, antiviral and antimitotic properties, blocking the cell cycle at early S-phase. This property has been used to synchronise cell division and is useful as a tool in cell differentiation research. Aphidicolin is a reversible inhibitor of DNA replication by inhibiting selected DNA polymerases. Aphidicolin induces apoptosis, prolongs the half-life of DNA methyltransferase, is active against Leishmania parasites and acts synergistically with the antitumor agents, vincristine and doxorubicin.
- X-Ray crystallographic determination of the structure of the antibiotic aphidicolin: a tetracyclic diterpenoid containing a new ring system. Brundret K.M. et al., J.C.S. Chem. Commun. 1972, 1027.
- The production of aphidicolin by Nigrospora sphaerica. Starratt A.N. & Loschiavo S.R., Can. J. Microbiol. 1974, 20, 416.
- Synchronization of cell division in eight-cell bovine embryos produced in vitro: Effects of aphidicolin. Samake S. & Smith L.C., Theriogenology 1997, 48, 969.
- Cytotoxicity of aphidicolin and its derivatives against neuroblastoma cells in vitro: synergism with doxorubicin and vincristine. Michaelis M. et al., Anticancer Drugs 2000, 11, 479.
- Antileishmanial activities of aphidicolin and its semisynthetic derivatives. Kayser O. et al., Antimicrob. Agents Chemother. 2001, 45, 288.