Antimycin A1

Antimycin A1

$255.00 - 0.50 mg

$894.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-A1442
CAS #
642-15-9
Molecular Formula
C28H40N2O9
Molecular Weight
548.6
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Clear

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Application Notes

Antimycin A1 is the most hydrophobic of the four analogues of the antimycin A complex. Like all antimycins, antimycin A1 exhibits potent antifungal, anthelmintic, insecticidal, antiviral and antitumor activity across a range of bioassays. Although broadly active as respiration inhibitors, more recent investigation has highlighted the importance of individual members of the complex as bioprobes. Antimycin A1 inhibits angiogenesis via a decrease in VEGF production caused by inhibition of HIF-1a activation.

References

  • Antimycin A1, an antibiotic with insecticidal and miticidal properties. Kido G.S. & Spyhalski E. Science 1950, 112, 172.
  • Inhibition of angiogenesis and HIF-1a activity by antimycin A1. Maeda M. et al., Biol. Pharm. Bull. 2006, 29, 1344.

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