Anydrofulvic acid is produced by several Penicillium and other fungal species. Anhydrofulvic acid has an essentially planar chromone ring system, with a coplanar carboxylic acid group. Anhydrofulvic acid possesses potent antifungal activity, inhibiting both endogenous and exogenous cellular respiration and strongly restricting biofilm production and hyphae formation in C. albicans by down-regulating several biofilm and morphogenesis-related genes. Anhydrofulvic acid is a collagenase inhibitor and has antiinflammatory and weak cytotoxic activity.
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