Ampicillin

Ampicillin

$56.00 - 25 mg

$195.00 - 100 mg

All prices in Australian dollars

Code
BIA-A2345
Synonyms
D-(-)-6-(α-Aminophenylacetamido)penicillanic acid, D-(-)-Ampicillin, D-(-)-α-Aminobenzylpenicillin, D-(-)-α-Aminopenicillin
CAS #
69-53-4
Molecular Formula
C16H19N3O4S
Molecular Weight
349.4
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO
Clear

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Application Notes

Ampicillin is a broad-spectrum, semi-synthetic beta-lactam antibiotic. The 2-amino-2-phenylacetamido group substituent at position 6 of the penam ring confers activity against Gram-negative bacteria, including Escherichia coli, Haemophilus influenzae, Salmonella Typhi and Shigella. Ampicillin binds to and inactivates penicillin-binding proteins located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, interrupting bacterial cell wall synthesis and resulting in the weakening of the bacterial cell wall and cell lysis.

References

  • Pharmacology and chemotherapy of ampicillin – a new broad-spectrum penicillin. Acred P. et al. Br J Pharmacol Chemother 1962, 18, 356.

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