Amphotericin B

Amphotericin B

$63.00 - 5 mg

$221.00 - 25 mg

All prices in Australian dollars

Code
BIA-A1441
Synonyms
Amphotericin
CAS #
1397-89-3
Molecular Formula
C47H73NO17
Molecular Weight
924.1
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Clear

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Application Notes

Amphotericin B is heptaene polyene antifungal originally discovered as a metabolite of Streptomyces nodosus in 1956. Amphotericin B acts by binding sterols in the cell membrane leading to the formation of transmembrane channels and subsequent ion leakage. Amphotericin B is poorly water soluble so has been developed for therapeutic use as a complex with desoxylate or in liposomes to improve bioavailability. Amphotericin B is widely used as a research reagent in diverse applications with over 15,000 literature citations.

References

  • Amphotericins A and B, antifungal antibiotics produced by a streptomycete. II. The isolation and properties of the crystalline amphotericins. Vandeputte J. et al., Antibiot. Annu. 1955-1956. 1956, 587.
  • Amphotericin B and its new derivatives – Mode of action. Baginski M. & Czub J. Current Drug Metabolism 2009, 10, 459.
  • Liposomal amphotericin B. Therapeutic use in the management of fungal infections and visceral leishmaniasis. Coukell A.J. & Brogden R.N. Drugs 1998, 55, 585.

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