$144.00 - 0.50 mg
$504.00 - 2.50 mg
All prices in Australian dollars
- FR 900220; WF 6237, Antibiotic FR 900220
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in ethanol, methanol, DMF or DMSO.
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Amauromine, a symmetric bis-dihydroindole, was first isolated from Amauroascus sp. by researchers at Fujisawa (now Astellas) in 1984 as a potent vasodilator. Amauromine has two prenylated dihydroindoles coupled through their respective 2- and 3-positions to a central diketopiperazine. Amauromine was later reported as a secondary metabolite in a related genus, Auxarthron, and its anamorphic genus, Malbranchea. Amauromine is a potent inhibitor of cannabinoid CB1 receptors with antagonistic activity at the cannabinoid-like orphan receptor GPR18.
- Structure of amauromine, a new alkaloid with vasodilating activity produced by Amauroascus sp. Takase S. et al., Tet. Lett. 1984, 25, 4673.
- Amauromine, a new vasodilator. Taxonomy, isolation and characterization. Takase S. et al., J. Antibiot. 1984, 37, 1320.
- Identification of a potent and selective cannabinoid CB1 receptor antagonist from Auxarthron reticulatum. Elsebai M.F. et al., Med. Chem. Lett. 2011, 2, 866.