Amauromine

Amauromine

$144.00 - 0.50 mg

$504.00 - 2.50 mg

All prices in Australian dollars

Synonyms
FR 900220; WF 6237, Antibiotic FR 900220
CAS #
88360-87-6
Molecular Formula
C32H36N4O2
Molecular Weight
508.65
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.
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Application Notes

Amauromine, a symmetric bis-dihydroindole, was first isolated from Amauroascus sp. by researchers at Fujisawa (now Astellas) in 1984 as a potent vasodilator. Amauromine has two prenylated dihydroindoles coupled through their respective 2- and 3-positions to a central diketopiperazine. Amauromine was later reported as a secondary metabolite in a related genus, Auxarthron, and its anamorphic genus, Malbranchea. Amauromine is a potent inhibitor of cannabinoid CB1 receptors with antagonistic activity at the cannabinoid-like orphan receptor GPR18.

References

  • Structure of amauromine, a new alkaloid with vasodilating activity produced by Amauroascus sp. Takase S. et al., Tet. Lett. 1984, 25, 4673.
  • Amauromine, a new vasodilator. Taxonomy, isolation and characterization. Takase S. et al., J. Antibiot. 1984, 37, 1320.
  • Identification of a potent and selective cannabinoid CB1 receptor antagonist from Auxarthron reticulatum. Elsebai M.F. et al., Med. Chem. Lett. 2011, 2, 866.

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