Alternariol

Alternariol

$158.00 - 0.10 mg

$553.00 - 0.50 mg

All prices in Australian dollars

Synonyms
NSC 638263
CAS #
641-38-3
Molecular Formula
C14H10O5
Molecular Weight
258.23
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO
Clear

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Application Notes

Alternariol was first reported by Raistrick and colleagues in 1953. Alternariol and its monomethyl ether analogue occur in mycelium of Alternaria tenuis responsible for alternaria cone disorder in hops and fruit spot on papaya (Carica papaya) and Passiflora spp. Alternariol forms reactive oxygen species and interacts with DNA topoisomerase, generating single- and double-strand DNA beaks. Alternariol represses immune responses in an inflamed environment, possibly leading to increased disease susceptibility, and may increase autophagic activity and induce senescence in macrophages.

References

  • Studies in the biochemistry of microorganisms. 90. Alternariol and alternariol monomethyl ether, metabolic products of Alternaria tenuis. Raistrick H. et al. Biochem. J. 1953, 55, 421.
  • Studies in the biosynthesis of fungal metabolites. 2. The biosynthesis of alternariol and its relation to other fungal phenols. Thomas R. Biochem. J. 1961, 78, 748.
  • Mechanisms of action and toxicity of the mycotoxin alternariol: A review. Solhaug A. et al. Basic Clin Pharmacol Toxicol 2016, 119, 533.

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