Alloxazine

Alloxazine

$53.00 - 25 mg

$186.00 - 100 mg

All prices in Australian dollars

Synonyms
2,4-Dioxobenzo[g]pteridine, 6,7-Benzolumazine, Benzo[g]pteridine-2,4(3H,10H)-dione, Flavoquinone, Isoalloxazine, NSC 203056, NSC 402746
CAS #
490-59-5
Molecular Formula
C10H6N4O2
Molecular Weight
214.18
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO
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Application Notes

Alloxazine, the tautomer of isoalloxazine which forms the backbone of vitamin B2, is a selective adenosine A2B receptor antagonist. Alloxazine is used as a scaffold for the design of new and selective kinase inhibitors as antitumor actives. Alloxazine has Anti-inflammatory and Antinociception effects in vitro.

References

  • Adenosine A2a and A2b receptors in cultured fetal chick heart cells. High- and low-affinity coupling to stimulation of myocyte contractility and cAMP accumulation. Liang B.T. et al. Circ. Res. 1995, 76, 242.
  • Functional characterization of the A2b adenosine receptor in NIH 3T3 fibroblasts. Brackett LE. and Daly J.W. Biochem. Pharmacol. 1994, 47, 801.
  • Structural-based design, synthesis, and antitumor activity of novel alloxazine analogues with potential selective kinase inhibition. Malki W.H. et al. Eur J Med Chem 2018, 152, 31.

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