Agaric acid

Agaric acid

$56.00 - 25 mg

$196.00 - 100 mg

All prices in Australian dollars

Code
BIA-A2596
Synonyms
Agaricic acid, Agaricin, Agaricinic acid, Laricic acid, NSC 60429, NSC 65690, α-Cetylcitric acid
CAS #
666-99-9
Molecular Formula
C22H40O7
Molecular Weight
416.55
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO
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Application Notes

Agaric acid is an adenine nucleotide translocase antagonist which induces mitochondrial permeability, promoting efflux of accumulated Ca2+, collapse of transmembrane potential, and mitochondrial swelling. Agaric acid has been used historically to inhibit sweating. Agaric acid inhibits both motility and biofilm formation in Salmonella Typhimurium.

References

  • A new inhibitor of adenine nucleotide translocase in mitochondria: agaric acid. Chavez E. and Klapp M. Biochem. Biophys. Res. Comm. 1975, 67, 272.
  • Agaric acid induces mitochondrial permeability transition through its interaction with the adenine nucleotide translocase. Its dependence on membrane fluidity. Garcia N. et al. Mitochondrion 2005, 5, 272.
  • The mechanism of sweat production by agaric acid. Hattori K. Berichte ueber die Gesamte Physiologie und Experimentelle Pharmakologie 1934, 86, 671.

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