$128.00 - 5 mg
$448.00 - 25 mg
All prices in Australian dollars
- 5-Pentadecyl-1,3-benzenediol, 5-Pentadecylresorcinol; Cardol
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in ethanol, methanol, DMF or DMSO.
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Adipostatin is a hydrophobic resorcinol metabolite first isolated from Streptomyces cyaneus as an inhibitor of glycerol-3-phosphate dehydrogenase by researchers at the University of Tokyo in 1992. Glycerol-3-phosphate dehydrogenase is an important enzyme for the regulation of adipocyte proliferation in the treatment of obesity. Adipostatin A inhibits the accumulation of triglycerides in model cells lines without affecting cell viability. Adipostatin A has antifilarial activity, identified in a high throughput assay using asparaginyl-tRNA synthetase from the filarial worm, Brugia malayi.
- Adipostatins A and B, new inhibitors of glycerol-3-phosphate dehydrogenase. Tsuge N. et al., J. Antibiot. 1992, 45, 886.
- Synthesis and biological evaluation of bilobol and adipostatin A. Tanaka A. et al., J. Asian Nat. Prod. Res. 2011, 13, 290.
- Adipostatins A-D from Streptomyces sp. 4875 inhibiting Brugia malayi asparaginyl-tRNA synthetase and killing adult Brugia malayi parasites. Rateb M.E. et al., J. Antibiot. 2015, 68, 540.