Actiphenol

Actiphenol

$221.00 - 1 mg

$774.00 - 5 mg

All prices in Australian dollars

Synonyms
Actinophenol, NSC 58413
CAS #
526-02-3
Molecular Formula
C15H17NO4
Molecular Weight
275.3
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO
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Application Notes

Actiphenol is a glutarimide antibiotic first reported in 1956 with antifungal and antitumor activity. Actiphenol is more active against coxsackievirus B3​, influenza virus A​, and herpes simplex virus 2 than synthetic glutarimides. The production of actiphenol and cycloheximide in Streptomyces is governed by the one gene cluster, an acyltransferase-less type I polyketide synthase.

References

  • Sttoffwechselprodukte von Actinomyceten, Actiphenol. Highet R.J. and Prelog J. Helv Chim Acta 1956 42: 1523–1526 (1956)
  • Synthesis and antiviral activities of synthetic glutarimide derivatives. Ji X. et al. Chem. Pharm. Bull. 2010, 58, 1436.
  • Cycloheximide and actiphenol production in Streptomyces sp. YIM56141 governed by single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase. Yin M. et al. Org. letters 2014, 16, 3072.

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