$166.00 - 0.10 mg
$581.00 - 0.50 mg
All prices in Australian dollars
- Aclacinomycin A, Aclacur, Antibiotic 3082A, Antibiotic 77-3082A, Antibiotic MA 144A1, Jaclacin, NSC 208734
- CAS #
- Molecular Formula
- Molecular Weight
- >90% by HPLC
- Long Term Storage
- Soluble in methanol or DMSO
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Aclarubicin (aclacinomycin A) is an anthracycline and topoisomerase II inhibitor that has been clinically tested against haematologic and solid tumors. Aclarubicin stabilizes topoisomerase I cleavage. Aclarubicin accumulates efficiently in the mitochondria of living human cells and leads to mitochondrial dysfunction. Aclarubicin inhibits reverse transcriptase, endothelin converting enzyme and collagenase, and is active against HIV.
- Antitumor activity of new anthracycline antibiotics, aclacinomycin-A and its analogs, and their toxicity. Hori S. et al. Gan 1977, 68, 685.
- Novel actions of inhibitors of DNA topoisomerase II in drug-resistant tumor cells. Beck W.T. et al. Cancer Chemother Pharmacol. 1994, 34 Suppl:S14-8.
- Aclarubicin, an anthracycline anti-cancer drug, fluorescently contrasts mitochondria and reduces the oxygen consumption rate in living human cells. Iihoshi H. et al. Toxicol. Lett. 2017, 277, 109.