3-Hydroxymycophenolic acid

3-Hydroxymycophenolic acid

$210.00 - 0.50 mg

$735.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-M3058
Synonyms
-
CAS #
172608-85-4
Molecular Formula
C17H20O7
Molecular Weight
336.3
Purity
>95% by HPLC
Long Term Storage
Soluble in methanol and DMSO.

Download Data Sheets

Application Notes

3-Hydroxymycophenolic acid is the lactol derivative of the immunosuppressant mycophenolic acid (MPA), bearing a hydroxy group at C-3 of the phthalide. 3-Hydroxymycophenolic acid demonstrates similar immunosuppressive potential to MPA, inhibiting the target inosine-5′-monophosphate dehydrogenase 2 with an IC50 value of 0.95 µM. 3-Hydroxymycophenolic acid is inactive against human gastric adenocarcinoma AGS and human lung fibroblast cell lines.

References

  • Jones D.F. et al. (1970). Microbial modification of mycophenolic acid. J. Chem. Soc., 12, 1725.
  • Zhang Q. et al. (2018). Mycophenolic acid derivatives with immunosuppressive activity from the coral-derived fungus Penicillium bialowiezense. Mar. Drugs, 16, 230.
  • Schmeda-Hirschmann G. et al. (2007). Biotransformations of imbricatolic acid by Aspergillus niger and Rhizopus nigricans cultures. Molecules, 12, 1092.

Other Products