WIN 66306

WIN 66306

$221.00 - 1 mg

$774.00 - 5 mg

All prices in Australian dollars

Synonyms
Cyclo[glycyl-​L-​tryptophyl-​L-​prolylglycyl-​L-​valylglycyl-​(βR)​-​β-​hydroxy-​3-​(3-​methyl-​2-​butenyl)​-​L-​tyrosyl]
CAS #
151928-32-4
Molecular Formula
C41H52N8O9
Molecular Weight
800.9
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO
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Application Notes

WIN 66306 is a cyclic peptide discovered during a search for inhibitors of Substance P binding to neurokinin (NK) receptors by researchers at Sterling Winthrop Pharmaceuticals in 1994. WIN 66306, isolated from Aspergillus sp., is active at both the NK1 and NK2 receptor subtypes and is more active against human NK1 receptors than rat NK1 receptors.

References

  • WIN 66306, a new neurokinin antagonist producted by an Aspergillus species; Fermentation, isolation and physicochemical properties. Barrow C.J. et al. J Antibiot. 1994, 47, 1182.
  • Structure determination, pharmacological evaluation and structure-activity relationship studies of a new cyclic peptide Substance P antagonist containing the new amino acid, 3-prenyl-β-hydroxytyrosine, isolated from Aspergillus flavus. Barrow C.J. et al. J Med Chem. 1994, 37, 356.

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