$233.00 - 1 mg
$816.00 - 5 mg
All prices in Australian dollars
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in methanol or DMSO
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Trypacidin, isolated from Aspergillus fumigatus, is related to the geodin group of antibiotics. Trypacidin is the most potent toxic principle of A. fumigatus conidia causing aspergillosis, displaying an IC50 of 7.4 µM against A549 lung cell line. Trypacidin is active in vitro against Trypanosome cruzi (MIC 5 – 10 µg/mL), Toxoplasma gondii (MIC 10 – 20 µg/mL). Trypacidin is moderately active against resistant and susceptible S. aureus with MIC values of 50 μg/mL, and significantly active against against B. subtilis and Mycobacterium bovis bacillus (BCG) with MIC values of 12.5 and 1.25 μg/mL, respectively.
- The structure of trypacidin. Balan J. et al. Acta Chem Scand. 1965, 2, 528.
- Antiprotozoan antibiotics. II Isolation and characterization of trypacidin A, a new antibiotic active against Trypanosoma cruzi and Toxoplasma gondii. Balan J. et al. J Antibiot. 1963, 16, 157.
- Trypacidin, a spore-borne toxin from Aspergillus fumigatus, is cytotoxic to lung cells. Gauthier T. et al. PlosONE 2012, 7, e29906.