Trinactin

Trinactin

$342.00 - 1 mg

$1,198.00 - 5 mg

All prices in Australian dollars

Code
BIA-T1094
Synonyms
AKD-1D, S 3466B
CAS #
7561-71-9
Molecular Formula
C43H70O12
Molecular Weight
779
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
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Application Notes

Trinactin is a member of the macrotetrolide complex produced by a range of Streptomyces sp. Early literature reported that trinactin was a monovalent cation ionophore with high selectivity for ammonium and potassium. Trinactin inhibits T-cell proliferation induced by IL-2, and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and interferon-γ. Trinactin has not previously been available for intensive investigation.

References

  • Effects of cyclosporin A and dinactin on T-cell proliferation, interleukin-5 production, and murine pulmonary inflammation. Umland S. P., et al., Am. J. Respir. Cell Mol. Biol., 1999, 20, 481.
  • Immunosuppressive effects of polynactins (tetranactin, trinactin and dinactin) on experimental autoimmune uveoretinitis in rats. Tanouchi Y., et al., Jpn. J. Ophthalmol., 1987, 31, 218.
  • Antibiotics as tools for metabolic studies. VI. Damped oscillatory swelling of mitochondria induced by nonactin, monactin, dinactin, and trinactin. Graven S. N., et al., Biochemistry, 1966, 5, 1735.

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