Thielavin A
Application Notes
The fungal metabolite, thielavin A, and its relatives are glucose-6-phosphatase inhibitors. The three benzoic acid units are essential for inhibition. Thielavin A was originally isolated as a inhibitor of prostaglandin biosynthesis. The closely related thielavin B is a telomerase and cell wall transglycosylation inhibitor.
References
- Thielavins as glucose-6-phosphatase (G6Pase) inhibitors: producing strain, fermentation, isolation, structural elucidation and biological activities. Sakemi S. et al., J. Antibiot. 2002, 55, 941.
- Inhibition of telomerase activity by fungus metabolites, CRM646-A and thielavin B. Togashi K. et al., Biosci. Biotechnol. Biochem. 2001, 65, 651.
- Screening systems for detecting inhibitors of cell wall transglycosylation in Enterococcus. Cell wall transglycosylation inhibitors in Enterococcus. Mani N. et al., J. Antibiot. 1998, 51, 471.