Pyrazine carboxylic acid

Pyrazine carboxylic acid

$56.00 - 25 mg

$196.00 - 100 mg

All prices in Australian dollars

Pyrazinoic acid, 1,4-Diazinecarboxylic acid, 2-Carboxypyrazine, 2-Pyrazinoic acid, NSC 13146, NSC 27192, Pyrazinic acid
Molecular Formula
Molecular Weight
>95% by HPLC
Long Term Storage
Soluble in methanol or DMSO

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Application Notes

Pyrazine carboxylic acid (pyrazinoic acid) is the active moiety of the antitubercular drug, pyrazinamide. Susceptible strains of Mycobacterium tuberculosis convert pyrazinamide to pyrazine carboxylic acid via nicotinamidase/pyrazinamidase. Pyrazine carboxylic acid inhibits fatty acid synthase type I in replicating tubercle bacilli, reaching 60% inhibition of fatty acid synthesis at pH 5.5. Pyrazine carboxylic acid targets the ribosomal protein S1 (RpsA) involved in protein translation and the ribosome-sparing process of trans-translation. Pyrazine carboxylic acid depletes cellular ATP reserves, inhibits renal tubular secretion of uric acid and is used as a chemical scaffold for new anti-TB drugs.


  • Pyrazinamide and pyrazinoic acid activity against tubercle bacilli in cultured human macrophages and in the BACTEC system. Salfinger M. et al. J Infect Dis. 1990, 162, 201.
  • Pyrazinoic acid and its n-propyl ester inhibit fatty acid synthase type I in replicating tubercle bacilli. Zimhony O. et al. Antimicrob Agent Chemother. 2007, 51, 752.
  • Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis. Shi W. et al. Science 2011, 333, 1630.
  • Identification and functional characterization of uric acid transporter Urat1 (Slc22a12) in rats. Sato M. et al. Biochim Biophys Acta 2011, 1808, 1441.

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