Pladienolide B
Application Notes
Pladienolide B is the major analogue of a family of macrocyclic lactones isolated from Streptomyces platensis by researchers at Eisai Corp. Japan in 2004. Pladienolide B is a highly potent inhibitor of both hypoxia induced VEGF expression and cancer cell proliferation. Pladienolide B binds to SF3b complex blocking the spliceosome and is an important bioprobe for our understanding of the spiceosome, a highly selective target for next generation antitumor agents.
References
- Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. III. In vitro and in vivo antitumor activities. Mizui Y. J. Antibiot. 2004, 57, 188.
- Splicing factor SF3b as a target of the antitumor natural product pladienolide. Kotake Y. et al., Nature Chemical Biology 2007, 3, 570.