Piericidin A

Piericidin A

$230.00 - 1 mg

$805.00 - 5 mg

All prices in Australian dollars

Code
BIA-P1069
Synonyms
Shaoguanmycin B, MT 1882-I, SN 198E, IT 143D, Piericidin A1
CAS #
2738-64-9
Molecular Formula
C25H37NO4
Molecular Weight
415.6
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

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Product Data Sheet

Application Notes

Piericidin A is the major analogue of a family of pyridyl antibiotics isolated from selected Streptomyces species. It is a specific, potent inhibitor of NADH-ubiquinone oxidoreductase (Complex I) that binds to ubiquinone binding site(s). Piericidin A inhibits both mitochondrial and bacterial NADH-ubiquinone oxidoreductases, binding close to NUOD-NUOB interface.

References

  • Evidence for a quinone binding site close to the interface between NUOD and NUOB subunits of Complex I. Prieur I. et al., Biochim. Biophys. Acta 2001, 1504, 173.
  • →H+/2e- stoichiometry in NADH-quinone reductase reactions catalyzed by bovine heart submitochondrial particles. Galkin A.S. et al., FEBS Lett. 1999, 451, 157.
  • The 49-kDa subunit of NADH-ubiquinone oxidoreductase (Complex I) is involved in the binding of piericidin and rotenone, two quinone-related inhibitors. Darrouzet E. et al., FEBS Lett. 1998, 10, 34.

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